Role of Ghrelin and Adiponectin among Type 2 Diabetes mellitus patients attended at Tertiary care teaching hospital

Abstract

Introduction: Diabetes mellitus (DM) refers to a bunch of disorders of metabolism that share the phenotypic sign of hyperglycaemia. Different variants of DM are caused due to the interaction of various genetic factors with environmental factors. Methods: overall total number of 50 patients with type 2 DM, aged from 20-60 years attending OPD of a tertiary hospital was taken into study, whose blood glucose level before meals was [≥ 120 mg/dl] and after meals was [≥ 140 mg/dl], taking oral hypoglycaemic medicines only and not taking insulin therapy was included in the examination. Result Overall, 50 patients of age group from 20-60 years were taken in the examination. among which type 2 DM was more predominant in the employed group from 51-60 years (48%) thereby 41-50 years (34%). It was seen that 52% of patient of type-II diabetes mellitus had history of same complaint in the family. From the research, polyuria (52%) and polydipsia (48%) were the commonest symptoms seen in the patients suffering from DM. According to the drug therapy recommendations, Biguanides (92.1%) and Sulfonylurea (87.2%) were the commonest prescribed oral hypoglycaemic medicines amongst entire oral hypoglycaemic group of medicines, followed by thiazolidinediones (19.2%), Dipeptidyl peptidase-4 inhibitors (16%), α-glucosidase inhibitor (3.2%) and meglitinides (1.9%) individually. Conclusion: The increasing pattern of inactive daily life routine and more occurrence of overweight has put up enhancement in the individuals of diabetes, which contributes to enormous requirement of hypoglycemic drugs and motivating corporations to spend much on research and development for producing targeted formulae.