A Comparative Study on the Cellular Inflammatory Indices among ICU Vs Non ICU Patients of Covid-19 in a Tertiary Hospital

Abstract

Background: As accumulating evidence has suggested that there is an association of increased levels of inflammatory bio markers in relation to severity of covid -19 illness, the present study was planned to examine the scenario of association between inflammatory markers and severity of covid-19 illness by studying ICU and non ICU patients comparatively. Research Question: Is there a positive association between increased levels of inflammatory biomarkers and severely ill patients of covid-19 disease? The setting of the study was at Government General Hospital, (State Covid Care Hospital) Vijayawada, Andhra Pradesh. An observational study was conducted during the period from March 2021 to August 2021 on 60 ICU and 40 Non ICU patients of covid-19 by studying their socio demographic profiles and scenario of increased levels of inflammatory Biomarkers in relation with severity of illness of covid-19 disease. Results: Maximum about 52% of the admissions were confined to the age group of 41 to 60 years with the mean ± 2 SD = 47.4 ± 24.8 at 95 CI with 70:30% of sex ratio was observed among study subjects as male & female. High CRP & IL 6 levels were observed among ICU patients when compared to Non ICU patients. Further it was observed that maximum high levels of serum ferritin between 501 to 750 Micrograms/L among ICU admissions of covid-19 significantly with the P< 0.01 when compared to non ICU admissions. And also high levels of LDH between 231-600 U/ml were observed among the both groups of ICU & non ICU patients. It was also observed that related to D dimer high levels ≥ 10,000 Micrograms/ml were noticed among ICU patients only. It was concluded that high levels of inflammatory Bio markers were associated with older and severely affected covid-19 patients in this study.