A study on thyroid profile in chronic liver disease patients admitted in a rural tertiary care hospital of West Bengal, India

Authors

  • Sudip Ray Senior Resident, Department Of General Medicine, Midnapore Medical College and Hospital, Medinipur, West Bengal, India
  • Sumesh PM Senior Resident, Department Of General Medicine, Midnapore Medical College and Hospital, Medinipur, West Bengal, India
  • Sukanta Dutta Senior Resident, Department Of General Medicine, Midnapore Medical College and Hospital, Medinipur, West Bengal, India
  • Nabodoy Majumder Senior Resident, Department Of General Medicine, Midnapore Medical College and Hospital, Medinipur, West Bengal, India
  • Umakanta Mahapatra Assistant Professor, Department Of General Medicine, Midnapore Medical College and Hospital, Medinipur, West Bengal, India
  • Bikash Chandra Swaika Professor, Department Of General Medicine, Burdwan Medical College and Hospital, Purba Bardhaman, West Bengal, India

Keywords:

Chronic liver disease, Thyroid profile (TSH, FT4, FT3, Total T3, rT3), CTP score, MELD score.

Abstract

Introduction: Abnormal thyroid function tests occur in various non-thyroidal illnesses, like chronic liver disease(CLD), where no pre-existing
hypothalamic-pituitary and thyroid gland dysfunction is present. Available studies reported decreased T3 and fT3 in most cases. But a limi ted
study reported the association of fT4, rT3 and TSH level with severity of CLD. Aim is to measure thyroid functions in patients with CLD and to
assess the severity of liver dysfunction in relation with thyroid functions a in tertiary care hospital. Methods: 100 patients of CLD were included.
Blood sample was analysed for Thyroid profile (TSH, FT4, FT3, total T3 and rT3), Serum LFT, Serum creatinine, Prothrombin time, INR and
USG of Hepatobiliary apparatus. Results were analysed to find out the correlation of thyroid profile with the severity of liver dysfunction
according to Child–Turcotte–Pugh (CTP) score and Model for End-Stage Liver Disease (MELD) score. Results: Majority of the patient had low
FT3 (90 %), Normal FT4 (58%), Normal TT3 (57%), high rT3 (57 %), and a normal TSH (72%). High TSH, low FT4, low FT3, low Tota l T3
(TT3) and high rT3 correlated with the severity of liver disease as per CTP score. High TSH, low FT3 and low total T3 correlated with the
MELD score. Conclusion: This study showed the existence of several abnormalities in thyroid function test in CLD, although euthyroidism was
maintained in the majority. Low FT3 and low TT3 might be used as a predictor of severity in CLD.

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Published

2022-01-17

How to Cite

Sudip Ray, Sumesh PM, Sukanta Dutta, Nabodoy Majumder, Umakanta Mahapatra, & Bikash Chandra Swaika. (2022). A study on thyroid profile in chronic liver disease patients admitted in a rural tertiary care hospital of West Bengal, India. International Journal of Health and Clinical Research, 5(2), 257–260. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/4102