A Descriptive Study of Serum Levels of 25-hydroxyvitamin D in Chronic Urticaria and its Association with Disease Activity

Abstract

Aim: To study the association of vitamin D- level in patients with chronic severe idiopathic urticaria and correlate their level with severity of disease.Material and methods: This was a hospital-based study conducted over a period of 1 year with a sample size of 30 patients diagnosed to have chronic idiopathic urticaria on basis of a recurrent eruption of wheals and flare with or without angioedema for each patient urticaria activity score(UAS) was calculated. Plasma 25-hydroxyvitamin D [25-(OH)D] levels were analyzed. A deficiency in vitamin D was defined as serum 25-(OH)D concentrations <30 ng/mL. The statistical analysis was carried out by using appropriate statistical tests.Results: Serum vitamin D3 level was significantly lower in chronic urticaria subjects. The prevalence of vitamin D deficiency (<30 ng/ml) was significantly higher in patients with chronic urticaria, with the mean value being 14.46ng/ml.Conclusion: The present study showed a strong positive correlation between vitamin D deficiency and chronic urticaria. This study also warrants that each subject with chronic urticaria should be screened for serum vitamin D3 levels before initiating treatment.