Assessing the effect of homocysteine compound levels and biological parameters on subjects undergoing hemodialysis
Keywords:Hemodialysis, homocysteine, renal disease, renal failure, urea, vitamin B6
Background: In subjects with renal disease, levels of homocysteine are raised leading to its excretion in urine. This correlation of raised homocysteine levels to renal disease can be attributed to the possible hypothesis that raised homocysteine can lead to renal disease or correlation of homocysteine to Glomerular Filtration Rate (GFR) where only a small fraction of less than 1% is only excreted. Aim: The present study was conducted to assess the effect of Homocysteine levels and biological parameters in subjects undergoing hemodialysis. Methods: In 120 subjects including both males and females with 57 controls and 63 cases. These subjects were within the age range of 19 years to 80 years and had a mean age of 46.6±4.22 years. Homocysteine and Vitamin B6 in the serum were assessed using the technology of ELISA using spectrophotometer, whereas, for evaluating urea and creatinine, electroluminescence was used with cobasd e411. The collected data were subjected to the statistical evaluation. Results: Homocysteine was 8.59±0.96 μmol/l in controls and was 22.97±4.77 μmol/l in the test group study subject (p<0.0001). Vitamin B6 levels were significantly lower in test subjects with 159.47±14.75 compared to the controls. Urea levels were significantly higher in test subjects having the renal disease with p<0.0001. Creatinine was significantly higher in test subjects having the renal disease. Creatinine value in controls was 0.45±0.12 and in test, subjects were 8.04±2.07 with p<0.000. B6 showed a negative correlation with homocysteine. With creatinine levels, homocysteine showed a positive correlation with an r-value of 0.187 and a p-value of 0.123. A similar positive correlation was seen with the urea levels with an r-value of 0.034 and a p-value of 0.792. Conclusion: The present study concludes that the levels of homocysteine, urea, and creatinine levels are raised in subjects having renal disease undergoing hemodialysis compared to the control subjects without renal disease. Also, Vitamin B6 and hemoglobin levels were significantly lower in subjects with renal disease undergoing hemodialysis compared to the subjects without renal disease.
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Copyright (c) 2022 BH. V. K. Praveen Varma, P.C. Mishra, M.K. Sagar, D.S.S.K. Raju
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