Psychopathology and Cognitiveimpairment in Patients with Hypothyroidism


  • Purkanti Shwetha Assistant Professor, Department of Psychiatry Ayaan Institute of Medical Sciences Kanakamamidii, RR District, Telangana, India


Hypothyroidism, Psychiatric morbidity, Psychopathology, Psychiatric disorders, Psychiatric symptoms, Cognitive Impairment.


Background and Objectives: Hypothyroidism is a chronic illness that affects the thyroid gland and is more common in women and the elderly. Patients with hypothyroidism are at a higher risk for psychiatric morbidity and cognitive impairment than the general population. No published Indian study in this precise topic has been identified by the current investigator to date. According to several findings, persons with hypothyroidism are more likely to have major psychiatric illnesses, psychiatric symptoms, or cognitive impairment. Among individuals with hypothyroidism, the researchers hope to determine the prevalence of psychiatric diseases, the frequency and character of psychiatric symptoms, and the presence of cognitive impairment.Methodology: It was decided to include 200 patients for the purpose of this investigation.A total of 100 patients with hypothyroidism and 100 patients with hypertension were assessed. The Mini International Neuropsychiatric Interview Plus (MINI Plus) was used to assess psychiatric disorders, the Comprehensive Psychopathological Rating Scale (CPRS) was used to assess psychiatric symptoms, and the Standardized Mini-Mental Status Examination (SMMSE) and the Brief Cognitive Rating Scale (BCRS) were used to assess cognitive functions in the study.Results: When compared to controls, patients with hypothyroidism experienced a higher rate of psychological morbidity.The frequency of psychiatric illnesses was found to be 52 percent in patients with hypothyroidism and 12 percent in individuals in the control group, with the difference being statistically significant in both cases. All patients suffering from Hypothyroidism was associated with psychiatric symptoms that did not fulfil the criteria for psychiatric illnesses, according to the study. In the domains of direction, language, and the building of SMMSE, patients with hypothyroidism demonstrated significantly substantial cognitive deficiencies compared to controls. In addition, they demonstrated highly severe cognitive deficits on the BCRS in the aggregate.Psychosomatic diseases, psychiatric symptoms, and cognitive impairment were all found to have a significant relationship with serum TSH concentrations. Additionally, there was a strong link between psychiatric diseases and serum FT4 levels.Conclusion: When comparing patients with hypothyroidism to those with hypertension, the prevalence of psychiatric disorders, psychiatric symptoms, and cognitive impairment is much higher in the hypothyroidism group.




How to Cite

Purkanti Shwetha. (2022). Psychopathology and Cognitiveimpairment in Patients with Hypothyroidism. International Journal of Health and Clinical Research, 5(3), 223–229. Retrieved from