Study of lipid peroxidation and antioxidant status in ischemic stroke patients
Keywords:Lipid peroxidation, Antioxidants, Ischemic stroke. Malondialdehyde, HDL.
Background: Oxidative stress is probably one of the mechanisms involved in neuronal damage induced by ischemia. During ischemia, high amounts of free radical formation together with reduced antioxidant defense causes oxidative stress that may play a role in the pathogenesis of stroke associated neuronal injury. Aim and objectives: To study the correlation between lipid peroxidation and antioxidant status in ischemic stroke patients in comparison with normal controls. Materials and Methods: Cross sectional study includes 50 Ischemic stroke cases and 50 healthy controls. Fasting Venous blood samples were collected in ischemic stroke patients within 24hours from the time of onset of stroke and blood levels of Lipid profile, Malondialdehyde, Vitamin C, Vitamin E and Uric acid are estimated in both cases and controls. Results: In the Ischemic stroke group total cholesterol, triglycerides and LDL levels were significantly increased and HDL level was significantly decreased. Malondialdehyde a lipid peroxidation product was significantly increased, while antioxidants Vitamin C and Vitamin E were significantly decreased. The other antioxidant Uric acid has increased significantly in cases when compared to controls. Conclusion: This study showed an altered antioxidant status in ischemic stroke patients, which may be an indirect proof for the existence of Lipid Peroxidation.
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Copyright (c) 2022 G. Srikanth Reddy, V. Siva Prabodh, T.D. Swetha
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