Serum leptin concentration in impaired glucose tolerance and recent onset type ii diabetes mellitus, relationship with anthropometry and lipid profile

Abstract

Diabetes as well as pre-diabetes or impaired glucose tolerance increases the risk of cardiovascular disease by 2–3 times and increases by as much as 50% the risks of non-cardiovascular mortality associated with this condition. This study aim is to measure serum leptin levels in correlatation with anthropometry and lipid profile in pre- diabetes, non-diabetic and diabetic men and women. A cross-sectional study has been carried out in a total of 45 subjects for 20 subjects of pre-diabetes , 20 subjects of diabetic and 5 non- diabetic, south Indian rural 23 women and 22 men. Anthropometry was done for all the subjects with calibrated weighing machine, height scale etc. There is strong association between anthropometry and leptin resistance in both impaired and diabetic groups. In women both groups well correlated with total cholesterol and LDL. Increased serum Leptin levels/ leptin resistance was more evident in pre- diabetics when compared to non-diabetic and recent on set diabetes men and women.