Clinical characteristics and laboratory findings of mild to moderate covid 19 cases admitted to tertiary care hospitals and their association with adverse outcomes

Abstract

Introduction:
The symptoms of COVID 19 are highly variable, classifying cases diagnosed with coronavirus disease (COVID 19) according to
their clinical characteristics and associated outcomes is important for management of this disease. Methods: Clinical characteristics of mild
moderate COVID 19 was studied at tertiary care f acilities in India. A total of 668 patients were analysed, their demographics, disease, clinical
characteristics and laborator y parameters were recorded and the association of these factors with adverse outcomes was analysed. Results: A total
of 668 patien ts were included in this study, of those 69 % were males and the overall mean age was 50.7 13.2 years . Comorbidities were
present in 530 patients and 32 patients were smokers, except 2 patients all were symptomatic at the time of admission. During hospit al stay,
eventually 124 (18.5%) required high flow nasal cannula , 71 (10.6%) required ventilator support and 5 (0.7%) succumbed to de ath. Majority of
patients i.e., 70% were discharged without any adverse outcomes. The factors significantly associated wit h adverse outcomes were age,
comorbidity, duration of stay, elevated CRP, SGPT, SGOT, INR, NT proBNP, IL 6, ferritin, D Dimer, and LDH; low platelet count and
hemoglobin. Conclusion: Clinical characteristics, hematological, inflammatory markers and biochem ical parameters can predict disease
progression and adverse outcomes.