Drug emergent metabolic syndrome among patients taking olanzapine: A prospective interventional study

Authors

  • Ashish Kumar Malik Assistant Professor, Department of Psychiatry, NC Medical College, Haryana, Punjab, India
  • Vivek Srivastava Senior Resident, Department of Psychiatry, Pt. BD Sharma PGIMS, Haryana, Punjab, India
  • Savinder Singh Director, Institute of Mental Health, Amritsar, Punjab, India
  • Deepika Dalal Assistant Professor, Department of Biochemistry, NC Medical College, Haryana, Punjab, India
  • Priyanka Tetarwal Senior Resident, Department of Anesthesia, NC Medical College, Haryana, Punjab, India

Keywords:

Olanzapine, Metabolic Syndrome, Weight gain, Atypical-antipsychotics.

Abstract

Introduction: Olanzapine is one of the most commonly used atypical antipsychotic and is associated with significant deterioration of the metabolic profile among the patients taking it. Aim: To assess the emergence of drug induced metabolic syndrome among patients taking olanzapine. Materials and method: Eighty cases with diagnosis of Schizophrenia, schizoaffective disorders, bipolar affective disorder, persistent delusional disorder, unspecified nonorganic psychosis and no history of treatment with atypical antipsychotics in last 6 months were recruited from outpatient/ inpatient department of Institute of Mental Health, Amritsar, by purposive sampling after baseline screening and applying inclusion and exclusion criteria. It was a Prospective Interventional study. Patients were assessed for their metabolic profile at baseline, 2- and 4- months. Result: Statistically significant difference was found in all the metabolic parameters, including body weight, blood pressure, BMI, fasting blood glucose, fasting triglycerides and fasting HDL, after 4 months of initiating olanzapine as compared to baseline. One-fifth of the patients had attained the criteria of metabolic syndrome at the end of four months, and this ratio showed minimal variation with gender. Conclusion: Metabolic impairments have become a persisting menace with currently preferred patterns of lifestyles and drug management. Psychiatrists must be vigilant enough towards the potential metabolic side effects of antipsychotic medications so that appropriate precautions can be implemented in a timely manner. The general treatment provided to patients with severe mental illness should be at par with care provided to other patients.

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Published

2022-01-18

How to Cite

Ashish Kumar Malik, Vivek Srivastava, Savinder Singh, Deepika Dalal, & Priyanka Tetarwal. (2022). Drug emergent metabolic syndrome among patients taking olanzapine: A prospective interventional study. International Journal of Health and Clinical Research, 5(3), 731–735. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/4802