Thyroid hormone regulation in acute myocardial infarction patients

Abstract

Aim: The aim of the present study was to evaluate changes in Free thyroid levels in patient of STEMI with cardiac markers Trop I and CKMB. Material and Methods: 100 Patients of STEMI were included. The diagnosis of STEMI based on the history of prolonged chest pain (> 30 min) was confirmed by ECG changes and with the help of biochemical markers like CK-MB, Troponin I and AST. 30 healthy subjects between 45- 70 years were taken as Control group.Results: The FT3 levels were on the lower side in patients of STEMI with cardiac markers on higher side, and the decrease was statistically significant. P<0.01. There was no significant difference in the serum concentration of FT₄ and TSH found between controls and cases. Conclusion: This study is conclusive, that there was decrease in mean serum FT₃ levels in patient of STEMI without significant changes in FT₄ and TSH as compared to controls. This downregulation of FT₃ was transient in patient of STEMI without complication and returns to normal or near to normal by the 7thday but patient with sever AMI with complication and marked increase in CK-MB, Troponin I, the FT₃ value still not came to normal levels.