Spectrum of manifestation of Primary extra nodal lymphomas - A retrospective case series and review of the literature.

Abstract

Objective: To study spectrum of manifestation and histopathological correlation of primary extra nodal NHL. Material and method: 15 cases of primary extra nodal NHL were included in this retrospective study. Clinical details include Age, gender, presenting symptoms were collected. Histopathological examination was performed. Immunohistochemistry was done based on histopathological morphology. Result: Out of the 15 subjects included in this study, 11 were male and 4 were female. 7 subjects were in the 5th decade of their lives. DLBCL (8 case) was most frequent variant of PENL followed by Anaplastic large cell lymphomas (3 case), Angioimmunoblastic T cell lymphoma (2 case) and Marginal zone lymphoma (2 case). Conclusion: Frequency of ENL is gradually increasing and has a highly variable clinical presentation. The clinician and pathologist should be aware of uncommon presentations. High level of suspicion will allow for an early diagnosis of pENL, which would in turn be helpful in improving the prognosis by early initiation of appropriate treatment.