Association of female Breast carcinoma, its prognostic factors and ABO blood group: A retrospective study

Abstract

Back ground: Association between ABO blood group antigens and cancer has been described since 1953. Association of breast carcinoma and ABO group is not clear. Aims and objectives: To study the association between blood group type and breast carcinoma, its prognostic factors and molecular subtypes. Material and methods: This is retrospective study which includes 273 breast cancer cases. Association between prognostic factors, molecular subtypes of breast carcinoma and blood group type was assessed. Results: Out of 273 cases of breast carcinoma, maximum number of cases were of O group (41.5%).Among grade 1 and grade 2 patients majority were having blood group O and grade 2 patients were having B group. All the blood groups showed tumor size of 2 to 5cms and were in stage 2 in maximum cases. Maximum cases with lymphnodal metastasis were seen in O group (45.1%).Her2 rich cases were commonly observed in B group (38%) where as Luminal A, Luminal B, and triple negative were commonly seen in O group (43.2%,46.3% and 39% respectively). Conclusion: Women with blood group O are at more risk of developing breast carcinoma followed by blood group B, A and AB. There was no statistical significance for association between the blood groups and prognostic factors of breast carcinoma. Lymph nodal metastasis was seen more in blood group O patients. Maximum number of Her2 rich cases were seen in B group whereas Luminal A, Luminal B and triple negative were seen in O group.