Assessment of Effect of Epidural Clonidine on Characteristics of Spinal Anaesthesia in Patients Undergoing Gynaecological Surgeries
Keywords:clonidine, spinal–epidural (CSE) anaesthesia, haemodynamics
Background: To assess the effect of epidural clonidine on characteristics of spinal anaesthesia in patients undergoing gynaecological surgeries. Materials & Methods: One hundred twenty patients belonging to American Society of Anesthesiologists physical status I and II who underwent gynaecological surgeries were randomly divided into 2 groups. Group I received clonidine (C) and group II received saline (S). Hyperbaric bupivacaine (15 mg) was administered intrathecally for both groups after epidural injection. Sensory and motor block characteristics, analgesia, sedation and haemodynamics were recorded in both groups. Results: Group I and group II had 60 females. The mean height in group I was 158.4 cm and inn group II was 157.3 cm. The mean weight in group I was 65.2 Kgs and in group II was 66.2 Kgs. Duration of surgery was 78.4 minutes in group I and 77.2 minutes in group II. The difference was significant (P< 0.05). Onset of sensory block at L1 (s) was 38.2 and 50.4, time to bromage 3 (s) was 55.4 and 102.3, time to 2 segment regression was 192.8 minutes and 109.3 minutes, total duration of analgesia was 312.4 minutes and 150.6 minutes and duration of motor blockage was 345.2 minutes and 124.7 minutes in group I and group II. The difference was significant (P< 0.05). VAS at 30 minutes was 1.5 in group I and 2.3 in group II, at 60 minutes was 1.4 in group I and 1.8 in group II, at 120 minutes was 2.6 in group I and 2.9 in group II, at 180 minutes was 2.1 in group I and 2.0 in group II and at 240 minutes was 1.5 in group I and 1.9 in group II. The difference was significant (P< 0.05). Conclusion: Administration of clonidine epidurally, 10 min before SAB, caused early onset and prolonged duration of motor blockade and analgesia.
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Copyright (c) 2022 Deepak S, Jitin George, Mohsin Mohammed Ali, Ashwin S John, R. C Krishna Kumar
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