The role of in-vivo proton magnetic resonance spectroscopy in gallbladder cancer patients: A metabolomic approach

Authors

  • Surender Kumar Professor, Department of General Surgery, King George Medical University, Lucknow, U.P., India
  • Nishant Ranjan Resident, Department of General Surgery, King George Medical University, Lucknow, U.P., India
  • Faraz Ahmad Associate Professor, Department of General Surgery, King George Medical University, Lucknow, U.P., India
  • Anit Parihar Professor, Department of Radio diagnosis, King George Medical University, Lucknow, U.P., India

Keywords:

MR Spectroscopy, Carcinoma gallbladder, Chronic cholecystitis, Gallstone disease, Metabolomics

Abstract

Background: Gallbladder carcinoma (GBC) is considered as a rare disease but it is the fifth most common malignancy of the gastrointestinal tract. Many diagnostic test are used to diagnose a case of GBC comprises laboratory studies and imaging tests.Proton MR Spectroscopy is able to detect and identify a large number of low concentration metabolites. It helps in detailed understanding of metabolic basis of physiology of disease and to diagnose the disease in its early stage.In this study we aim to identify the metabolides in benign malignant and normal gall bladder tissue and compare the metabolic profile of gall bladder tissue with histopathology report. Methods: The cross sectional study, total 119 patients were included in this study on the basis of well explained inclusion and exclusion criteria. Group I includes 51 patients with car cinoma gall bladder, Group II consists of 41 patients of benign gall bladder disease and Group III contain 27 patients with diseases other than hepato-biliary disease. 1H NMR metabolic profiling was done for the detection in metabolic changes. The Chi-square test, student’s t test and ANOVA were used for statistical analysis. Results: The area under curve of choline peak was significantly greater in group I (66.71) as compared to group II (14.85) and group III (5.44). The Lipid AUC and Lipid/Choline Ratio were significantly reduced in group I (222.61 and 5.01) as compared to group II (242.46 and 22.81) and group III (254.56 and 71.32). The Bilirubin total, Bilirubin Direct, SGPT, SGOT and ALP were significa ntly higher in group I. The change of MRI mass/ stone size was significantly positive correlated with choline AUC. Conclusion: The in-vivo MRS is a good tool to differentiate the malignant and benign Gallbladder tissue on the basis of metabolic profile of Gallbladder tissue with short time consuming, with no increased risk of contamination and metastasis of disease and good tool to differentiate between malignant and benign.

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Published

2022-01-17

How to Cite

Surender Kumar, Nishant Ranjan, Faraz Ahmad, & Anit Parihar. (2022). The role of in-vivo proton magnetic resonance spectroscopy in gallbladder cancer patients: A metabolomic approach. International Journal of Health and Clinical Research, 5(2), 991–996. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/5063