A prospective randomized trial on alkalinized lignocaine preloaded endotracheal tube cuffs to reduce emergence cough following brief surgery

Abstract

Background and Objectives: Endotracheal intubation is required during general anesthesia to secure the airway. As a result of coughing during emergence, patients have hypertension, tachycardia, elevated intracranial and intraocular pressure, bronchospasm, wound dehiscence, and surgical bleeding. Our goal is to determine whether alkalinized lignocaine preloaded endotracheal tube cuffs are effective at reducing the emergence of cough following minor surgery.
Methods: This prospective randomized controlled trial was conducted on ASA grade I and II patients between the ages of 25 and 50 after gaining approval from the institutional ethics committee, They were scheduled for a variety of short-duration surgeries under general anesthesia at Alluri Sita Rama Raju Academy Of Medical Sciences Hospital for one year. A total of 100 patients are divided into two groups, Group AL, and Group S (50 patients in each Group). Group AL: (study group) these patients received preloaded (alkalinized lignocaine in ET cuff 90 min before intubation) 2% alkalinized lignocaine in the ET cuff, volume decided by minimum occlusion volume technique. Group S: (control group): these patients received normal saline in the ET cuff after intubation.
Results: Patients in the AL Group had a mild cough in 12% of the population, while Patients in the S group had a mild cough in 14%, moderate cough in 10%, and severe cough in 4% of the group population. Emergence cough is significantly less in the AL group compared to the S Group (p=0.39).
Conclusion: Alkalinized lidocaine in ETTs preloaded with the same solution before surgery appears to significantly lower the incidence of emergency cough during short surgical procedures. Eliminating the pressor reaction also lessens emergence agitation and offers hemodynamic stability during extubation.