C-Reactive Protein As An Effective Biologic Factor In Covid-19 Patients: An Evidence Based Study

Abstract

Introduction: Coronavirus diseas-2019 (COVID-19) has been an emerging global health threat since its outbreak. The hospitalized COVID-19 patients are monitored regularly, but anytime they could develop mild and moderate symptoms into a severe disease course is challenging. However, early identification and diagnosis of the patients progressing to severity is essential to start a more relevant treatment that profoundly would help to improve the percentage outcomes of COVID-19 recovery. The present aims to investigate the serum C-reactive protein (CRP) levels in COVID-19 patients and its prognostic value. The C- reactive protein could prove to be an effective biologic factor in COVID-19 Patients.
Methods: After clinical examination of patients, routine blood investigation, for example CBC, KFT, LFT, serum electrolytes, D-dimer and CRP was done. The 5ml of peripheral blood was collected from each study subject, which was aliquoted in clot activator (Red top tube) vials until furhter processing. The separted serum was used for the crictical diagnostic estimation of CRP, using CS400 fully Automatic Biochemical Analyzer.
Results: The preliminary results have shown a significant difference in CRP levels in COVID-19 patients. Significantly, the severe patients had higher CRP levels than the moderate ones p-value < 0.05, also the COVID-19 infected patients who have under lying medical conditions had higher levels of CRP as compared to the patients who were having normal conditions prior to COVID-19 infection, p-value < 0.05.
Conclusion: The out come of the results indicate that the C- reactive protein could be an interesting molecule to determine early symptoms of COVID-19 Patients.