Diagnostic Accuracies of APRI and FIB4 For Predicting Different Stages of Liver Fibrosis In Patients of NAFLD and its Correlation With Fibroscan

Abstract

Aim: To analyse the diagnostic Accuracies of APRI and FIB4 for predicting different stages of liver fibrosis in patients of NAFLD and its correlation with Fibroscan. Material and methods: The present study prospective, observational study was conducted among 100 NAFLD patients, diagnosed by USG of both genders were recruited for the study. The laboratory test results that were evaluated included those in the hospital information. All results were obtained within one month of a Fibroscan examination. The cutoff values used for the diagnosis of severe fibrosis were: APRI>1, NAFLD score>0.676 and FIB-4 score >3.25. Results: Mean AST/ALT, APRI and FIB-4 was found to be more in F3+F4 grade as compared to F1+F2 grade. A statistically significant positive correlation was observed between APRI, FIB- 4 when compared to Fibrosis stages as statistically confirmed using Pearson correlation test. FIB- 4 has the best sensitivity while APRI has the best specificity in predicting different stages of liver fibrosis among patients of NAFLD. Hence APRI and FIB-4 was comparable in this study to predict liver fibrosis. Conclusion: We found APRI to be the best index to predict advanced liver fibrosis compared to AST/ALT ratio while comparable with FIB-4, with this index having the strongest correlation with FibroScan results.