Formulation Development & Evaluation of Floating tablets containing anti-diabetic drugs using different polymers

Abstract

The objective of the present study was to develop a pharmaceutically equivalent, stable, robust, cost effective and quality improved formulation of Glimepiride Non-effervescent floating tablets by using different grades of controlled release polymer. The design of dosage form was performed by choosing HPMC K 100M, HPMC K15M, HPMC K4M, Accural, MCC Magnesium stearate, and Talc in different ratios. The drug-polymer compatibility studies were performed. Blend Uniformity was studied and accordingly the flowability was optimized for the powder blend. Tablets were prepared by direct compression with free flowing powder. The network formed by HPMC, MCC and DCP had been coupled satisfactorily with the controlled resistance, in vitro release and FT-IR. Mean dissolution time was also reported to compare various dissolution profiles. The formula was finalized by comparing the in vitro dissolution with that of the innovator SR and IR tab.