Covid-19 associated coagulopathy with comparison of platelet parameters, PT, aPTT and D-Dimer in ICU and Ward patients

Abstract

Background: SARS-COV2 is the third known corona virus responsible for fatal respiratory illness in humans. Emerging evidence suggested that severe COVID-19 may be complicated with coagulopathy. These coagulation parameters help in assisting the prognosis of the disease and in optimization of its clinical monitoring. Aims: To assess and compare the coagulation parameters (platelet parameters, PT, aPTT, D-dimer) amongst ward and ICU patients of COVID-19 disease. Settings and Design: The present study was Analytical Cross-Sectional Study. Materials and Methods: This study included 220 COVID-19 positive cases (110 ICU and 110 Ward) at a tertiary care hospital. Tests were done for platelet parameters, PT, aPTT and D-Dimer in ICU and Ward patients. Statistical analysis used: The presentation of the Categorical variables was done in the form of number and percentage (%). The quantitative data were presented as means ± SD and as median with 25th and 75th percentiles (interquartile range). Results: In this study, we compared coagulation parameters (Platelet count, PT, aPTT, D dimer) of 110 ICU and 110 Ward covid-19 patients. We found that PT, aPTT, platelets, PDW cv and PCT between Covid ICU and ward patients had no significant difference (p value>0.05). Patients admitted to ICU had higher D-dimer level and decreased platelet count. There was clear significant difference in levels of D- dimer, platelet count and MPV between two groups (ICU and ward, p value<0.05). Conclusion: It is clear that alterations in the coagulation parameters in COVID-19 patients are strongly disturbed and signify the disease progression, severity and mortality.