Advances in Regenerative Endodontics: Pulp Revitalization and Future Directions

Abstract

Regenerative endodontics has become an innovative form of treatment in the field of dentistry
forcing a paradigm shift in dental practice to current root canal treatment to one that views the
endodontic field as biologically driven pulp regeneration. The profession focuses on the
regenerative treatment of the pulp-dentin unit using the stem cell, regenerative scaffold, and
growth factors to restore the vitality of the tooth and extend its functional life. The innovations in
the field of imaging technologies, like cone-beam computed tomography, have improved the
accuracy of the diagnostics and regenerative outcome monitoring. Moreover, the inclusion of AI
in endodontics practice will provide the chance of precise selection of cases, treatment planning,
and prognostication of outcomes. There is clinical evidence that regenerative protocols can play
not only a structural reinforcement role in teeth treated endodontically or have positive
indications in both immature and mature permanent dentition. Even though much has been done,
there are still setbacks regarding standardization of treatment mechanisms, the promise of
definite results and barriers to translation. Future perspectives hold the promise of integration
between biomaterial science, nanotechnology and artificial intelligence-based predictive
modeling in optimizing pulp revitalization and making regenerative endodontics a full-fledged
modality.