Clinical and Laboratory Profile of Children Presenting With Seizure in A Tertiary Care Hospital: An Observational Cross Section Study

Abstract

Background: Seizure is one of the common causes of childhood hospitalization with significant mortality and morbidity. Current study is to find type, clinical, demographic, biochemical profile and neuroimaging of children presenting with  seizure to tertiary center in Department of pediatrics Government Medical College and Hospital, Aurangabad. Subjects & Methods: This was a hospital based, prospective cross-sectional study conducted in Department of pediatrics Government Medical College and Hospital Aurangabad. Total 260 children between the age of 1 months to 12 years attending epilepsy clinic during the study period, were studied for clinical features, types, biochemical profile, imaging studies, EEG, etc. Results: Higher prevalence in the age group of 1 month to 1 year with male predominance (male/female = 1.6: 1) was found. In the present study Loss of consciousness (35.76 %), fever (25.76 %), vomiting (23.84 %), and headache (10.38 %) were four leading clinical complaints observed in children presenting with seizures . Generalized tonic-clonic seizures were the most common seizure semiology among the study cases. Conclusion: Appropriate study on clinical, demographic, biochemical profile and neuroimaging study of patients can help in proper understanding of the disease burden and to take appropriate measures for its control.

Keywords: Electroencephalogram (EEG), Computed tomography (CT), Magnetic resonance Imaging (MRI), generalized tonic clonic Seizure (GTCS)