Observational Study To Evaluate the role of LV Diastolic Dysfunction as An Earliest Marker of Diabetic Cardiomyopathy and Correlate with HbA1c, age and duration of diabetes in normotensive asymptomatic Type 2 diabetes mellitus (T2DM) patients

Abstract

Objective and AIM: Over the last two decades worldwide the prevalence of type 2 diabetes (T2D) has almost doubled and increasing in a rapid progression. Among cardiovascular complications of diabetes, Heart Failure (HF) considered as most common one. The main objective of this study was to evaluate the role of LV diastolic dysfunction asan earliest marker of diabetic cardiomyopathy and correlate with HbA1c, age and duration of diabetes in normotensive asymptomatic Type 2 diabetes mellitus (T2DM) patientsMaterial and Method: This is a retrospective observational study conducted at a primary diabetes and cardiology clinic OPD among 75 patients whose clinical records are well maintained or fully available at the clinics registry. After getting individual patient consent the data collected and analysed to draw a study conclusion. Results: Average mean age of the participants were 55.72±16.7 years with average duration of diabetes of 7.87±7.13 years. Left ventricular diastolic dysfunction was present in 47 patients. To detect diastolic dysfunction among participated patients E/A ratio < 1 were considered. 0.74±0.12 were the mean E/A ratio among the patient who had diastolic dysfunction and without diastolic dysfunction it was 1.34±0.19. In female and males left atrial size was compared in this study and found to be significantly increased in both the sex who had diastolic dysfunction. Mean HbA1c of 8.93±1.6 % were found in patient with diastolic dysfunction. with diastolic dysfunction average age for patients of patients were 57.29±14.3. Conclusion: Diastolic function affects before systolic function in patients with diabetes because of myocardial damage during the process. In diabetic patients with diastolic dysfunction, E/A ratio is significantly altered. Before actual clinical manifestation appears early detection of myocardial injury and diagnosing diastolic dysfunction can retard the progression of further myocardial injury.