Current Recommendations on MMRV combination vaccine in India

Authors

  • Kripasindhu Chatterjee Professor, Department of Pediatrics, Gouri Devi Institute of Medical Science and Hospital, Durgapur, West Bengal, India
  • Amit Dutta Professor, Department of Obstetrics and Gynaecology, Gouri Devi Institute of Medical Science and Hospital, Durgapur, West Bengal, India
  • Pradyut Kumar Mandal Professor, Department of Pediatrics, ICARE Institute of Medical Science and Research, Haldia, West Bengal, India
  • Arup Kumar Basu In-Charge SNCU, Santipur State Hospital, Santipur, West Bengal, India
  • SK Rafikul Rahaman Professor & Head, Department of Pediatrics, ICARE Institute of Medical Science and Research, Haldia, West Bengal, India
  • Sukanta Sen Professor & Head, Department of Pharmacology, ICARE Institute of Medical Science and Research, Haldia, West Bengal, India

Keywords:

Immunization, MMRV vaccine, Immunogenicity, Seroconversion rate, Advisory Committee on Immunization Practices (ACIP).

Abstract

Two MMRV vaccines have been available since 2000. ProQuad (Merck & Co., Inc, West Point, PA; Merck) and Priorix-Tetra (GlaxoSmithKline Biologicals, Rixensart, Belgium; GSK). Both have been widely used in USA, Australia, Canada, and many European countries. The MMRV vaccine was developed based on the existing MMR and varicella vaccines 1,2. Licensed ProQuad and Priorix-Tetra have different measles virus strains (Edmonston strain and Schwarz strain, respectively) with the same titer ( > 10 3.0 tissue culture 50% infective dose, TCID50). Mumps virus strain in Priorix-Tetra (RIT 4385 strain, titer > 10 4.4 TCID50) is derived from what is used in ProQuad (Jeryl Lynn strain, titer > 10 4.3 TCID50). ProQuad and Priorix-Tetra have same rubella virus strain (Wistar RA 27/3 strain) and titer (>10 3.0 TCID50). They also have same varicella virus strain (Oka strain), but with different titers (> 10 3.99 and > 10 3.3 plaque-forming units, respectively).

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Published

2021-03-15

How to Cite

Chatterjee, K., Dutta, A., Mandal, P. K., Basu, A. K., Rahaman, S. R., & Sen, S. (2021). Current Recommendations on MMRV combination vaccine in India. International Journal of Health and Clinical Research, 4(5), 264–267. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/1130

Issue

Vol. 4 No. 5 (2021): Volume 4 Issue 5| March 2021

Section

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