Serum CRP as a prognostic biomarker of delirium

Abstract

Abstract
Introduction: Serum CRP (C-reactive protein) is frequently measured in clinical practice, but its clinical relevance with delirium is not well studied. Aim:To study clinical significance of serum CRP in relation to severity, mortality and long-term consequence of delirium (development of dementia). Methodology: Sixty five elderly patients (age ≥ 60years) with delirium admitted in geriatric mental health department were recruited in this study. Underlying dementia was assessed using IQCODE-SF (Informant Questionnaire on Cognitive Decline-short form). Severity of delirium was assessed using DRS98-R (Delirium rating revised scale). Venous blood samples for serum CRP were collected on first day and seventh day of admission. Serum CRP levels were correlated with severity, duration of hospital stay, improvement, and mortality of delirium. Delirious patients without underlying dementia were followed up for 6 months for development of dementia and their cognition was assessed using HCST (Hindi cognitive screening test). Results: In seven days of admission delirium improved in 35 patients, while delirium didn’t improve in 25 patients and 5 patients died. Serum CRP improved with improvement of delirium. (P= 0.001). No significant correlation found between serum CRP, severity of delirium and mortality. Serum CRP was significantly higher in delirious patients who developed dementia in compare to those who didn’t develop dementia. Conclusion: Higher level of serum CRP in patients with delirium doesn’t predict the severity of delirium and mortality, but it predicts the development of dementia in future.
Keywords: C-reactive protein, Serum, Delirium.