Circulating serum C- reactive protein: a prognostic marker in naive patients with cancer at the Yaounde General Hospital
Keywords:
CRP, cancer, inflammation, prognosticAbstract
In Cameroon, the main determinant of cancer mortality is the advanced stage at the time of diagnosis. The purpose of this work is to determine the relationship between C-reactive Protein (CRP) concentration and advanced cancer stage. This is a cross-sectional study conducted at Yaoundé General Hospital. 276 naive patients with histological evidence of cancer were included in this study. Serum CRP level was correlated with the specific characteristics of the tumor. The study population was made of 74% women and 26% men with a minimum age of 22 years and a maximum age of 80 with an average age of 46 years. The cancer type with the highest prevalence was breast cancer (43.5%), followed by Kaposi's sarcoma (8.7%), Non Hodgkin Lymphoma (8.7%), CRP values were Classified into two groups based on pathological values (CRP≥ 6 mg/l) and non-pathological values (CRP <6 mg/l). The elevated CRP concentration was not significantly associated with the presence of metastasis M (P = 0.074), T-cancer stage (P = 0.09), N-lymph nodes (P = 0.111), advanced histological grade G-3 (P = 0.115) and cancer type (P = 0.124). Our study shows that elevated serum CRP is not a marker of cancer extension.
References
2. Reuter S, Gupta SC, Chaturvedi MM and Aggarwal BB. Oxidative stress, inflammation,and cancer: How are they linked? Free Radical Biol Med. 2010 ; 49(11), 1603‑1616.
3. Al Ghazal A, Steffens S, SteinestelJ, Lehmann R, Schnoeller TJ, Schulte-Hostede A and Kuczyk MA. Elevated C-reactive protein values predict nodal metastasis in patients with penile cancer. BMC urology. 2013;13(1), 53.
4. Allin KH, Nordestgaard BG, Flyger H and Bojesen SE. Elevated pre-treatment levels of plasma C-reactive protein are associated with poor prognosis after breast cancer: a cohort study. Breast Canc Res. 2011;13(3), R55.
5. Xia WX, Ye YF, Lu X, Wang L, Ke LR, Zhang HB and Cao KJ. The impact of baseline serum C-reactive protein and C-reactive protein kinetics on the prognosis of metastatic nasopharyngeal carcinoma patients treated with palliative chemotherapy. PloS one, 2013; 8(10), e76958.
6. Bray F, Ren JS, Masuyer E and Ferlay J. Global estimates of cancer prevalence for 27 sites in the adult population in 2008. Int J Canc. 2013; 132(5), 1133‑1145.
7. MORIN R. Amelioration of the ultrasonore imagery resolution. PhD thesis. 2013. University of Toulouse, France
8. Au W, Weisenburger DD, Intragumtornchai T, Nakamura S, Kim WS and Sing I. Clinical differences between nasal and extranasal natural killer/T-cell lymphoma: a study of 136 cases from the International Peripheral T-Cell Lymphoma Project. Blood. 2009;113(17), 3931‑3937
9. Cao Y, Shi Y, Chen J, Tan Y, Cai YC, Luo H and Jiang W. Serum C-reactive protein as an important prognostic variable in patients with diffuse large B cell lymphoma. Tumor Biol. 2012;33(4), 1039‑1044.
10. Li YJ, Li ZM, Xia Y, Huang JJ, Huang HQ, Xia ZJ and Jiang WQ. Serum C-reactive protein (CRP) as a simple and independent prognostic factor in extranodal natural killer/T-cell lymphoma, nasal type. PloS One. 2013; 8(5), e64158.
11. Chen HH, Chen IH, Liao CT, Wei FC, Lee LY and Huang SF. Preoperative circulating C-reactive protein levels predict pathological aggressiveness in oral squamous cell carcinoma: A retrospective clinical study: CRP in oral squamous cell carcinoma. Clinical Otolaryngology. 2011; 36(2), 147‑153.
12. Ishizuka M, Nagata H, Takagi K and Kubota K. (). C-Reactive Protein is Associated with Distant Metastasis of T3 Colorectal Cancer. Anticancer Res. 2012 32(4), 1409‑1415.
13. Neuss H, Koplin G, Raue W, Reetz C and Mall JW. Analysing the serum levels of tumour markers and primary tumour data in stage III melanoma patients in correlation to the extent of lymph node metastases--a prospective study in 231 patients. Acta Chirurgica Belgica.2011; 111(4), 214‑218.
14. Heikkilä K, Ebrahim S and Lawlor DA. A systematic review of the association between circulating concentrations of C reactive protein and cancer. J Epidemio Community Health. 2007; 61(9), 824‑833.