A Hospital Based Comparative Study to Evaluate the Efficacy of 150 Mgs of Oral Pregabalin and 6 Mg Oral Melatonin Used as Premedication to Attenuate Stress Response and Haemodynamic Responses in Cholecystectomy for Laparoscopic Surgery
Keywords:Cholecystectomy, Laparoscopy, Hemodynamic Changes, Premedication.
Background: Airway management is one of the core skills of the anesthetists. Various studies have been performed to study efficacy of drugs on attenuating haemodynamic responses to laryngoscopy. By far no study has been done to compare oral pregabalin & oral melatonin. This study was conducted to evaluate & compare efficacy of oral pregabalin & oral melatonin in attenuation of haemodynamic responses during laryngoscopy, intubation & extubation in laparoscopic cholecystectomy.Materials & Methods: This is a hospital based prospective study done on 50 Patients undergoing laparoscopic cholecystectomy in department of anaesthesiology in Dr. S. N. Medical College, Jodhpur. Patients were randomly divided into two groups of 25each with the help of achitbox method. Group P - (25 patients) oral pregabalin 150 mg, 120 min before surgery and group M-(25patients)oral melatonin tablets 6mg (two tablets of 3 mg), 120 min beforesurgery. Data are expressed as mean, intra group difference was evaluated by two-way analysis of variance(ANOVA),and intergroup usingt-test. P values of <0.05 were considered significant. Results: Our study showed that the mean age of patients was 37.34±10.78 years in group P and 35.38±12.45 years in group M, but statistically non-significant (P>0.05). The female to male ratio was 3:2 in both groups, female preponderance in our study. The SBP, DBP & MAP in group M was slightly lower as compare to group P, but statistically nonsignificant at baseline after 1 min., 3 min. & 30 after pneumoperitoneum in between groups. During laryngoscopy & intubation after pneumoperitoneum & after extubation the haemodynamic changes was statistically significant.Conclusion: We concluded that both the drugs can be used as an effective premedicant to attenuate the sympathetic response to laryngoscopy and tracheal intubation without more side effects.
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Copyright (c) 2021 Anisha Banu, Jogendra Singh Rajpurohit, Yogesh Tarani
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