Comparative analysis of Magnesium Sulphate Versus Clonidine as an Adjuvant to Epidural Bupivacaine 0.5% in Lower Abdominal and Lower Limb Surgeries

Abstract

Introduction: A prospective, randomized, controlled clinical trial was carried out to evaluate the effects ofMagnesium sulphate as an adjuvant to epidural bupivacaine and compared with clonidine along with epidural bupivacaine.Aims and Objective: Main objective to evaluate the efficacy of epidural magnesium sulphate& clonidineused as an adjuvant to bupivacaine.Material and method: After approval from institutional ethical committee 60 patients undergoing lowerabdominal &lower limb surgeries selected and divided in 2 groups Clonidine group and Magnesium group and different parameters observed.Observation: Co-administration of inj. Magnesium sulphate 50 mg. or Clonidine 3μg/kg (150μg maximum) to epidural bupivacaine produced predictable rapid onset of surgical anaesthesia without significant side effects. Addition of clonidine to epidural bupivacaine produced prolonged duration of analgesia with mild sedation compared to magnesium sulphate.Conclusion: From the study it is suggested that magnesium sulphate can be a useful alternative as anadjuvant to epidural bupivacaine without any side effects.