Evaluation of histomorphology of prostatic adenocarcinoma and its mimics

Abstract

Background:Prostatism is a companion of the geriatric age group and is associated with prostatic disease that leads to significant morbidity worldwide. The present study was conducted to evaluate histomorphology of prostatic adenocarcinoma.Materials & Methods: The present study was conducted among 40 radical prostatectomy and transurethral resection of the prostate (TURP) specimens received in the pathology department. A history followed by a clinical examination, digital rectal examination (DRE), and transrectal ultrasound (TRUS) findings were recorded. The received specimens were fixed in 10% neutral buffered formalin, and routine paraffin processing was done, followed by hematoxylin and eosin (H and E) staining of sections. Serum prostate-specific antigen (PSA) levels was assessed. All the slides were examined under microscope. Older Gleason's grading system was used for grading the carcinomas.Results: Histological mimics of prostatic adenocarcinoma were basal cell hyperplasia in 8, clear cell cribriform hyperplasia in 3, prostate atrophy in 1 and atypical adenomatous hyperplasia in 2 cases. The serum PSA level <4 mg/ml was seen in 4, 4-10 mg/ml in 6 and >10 mg/ml in 16 prostatic adenocarcinoma cases and <4 mg/ml in 11, 4-10 mg/ml in 2 and >10 mg/ml in 1 mimickers of carcinoma. Conclusion: Biopsy still remains a gold standard for diagnosis of prostate adenocarcinoma and its mimics