A study on clinical, etiological and laboratory profile in patients with jaundice at a tertiary care centre in south bihar

Abstract

Introduction: Jaundice is a major components of the syndrome of liver failure, which can be acute, subacute or chronic. Subacute and chronic liver failure are well-recognized syndromes with known causes of liver disease. While viral hepatitis and acetaminophen overdose are major causes of acute liver failure, there are many other infections and non-infectious causes that can mimic this presentation especially in a tropical country like India.

Aim and objective: To study the clinical profile, etiology and laboratory findings in different patients with jaundice. Methodology: An observational study was conducted in General Medicine department in Narayan Medical College and Hospital, Jamuhar. Total 100 patients were selected from OPD and IPD of Narayan medical college and hospital with jaundice being treated and fulfilled inclusion and exclusion criteria. The study was conducted between  Dec 2019 to June 2020. Result: Most common cause of jaundice came out to be viral hepatitis making a total of 60 cases (60%), with 23 cases of females (23%) and 37 cases of males (37%). Among the viral hepatitis the highest number of cases were of HEV (26%), followed by HBV (21%), HAV(16%) and HCV(1%). Next most common cause of jaundice came out to be Malaria (12%), Dengue (5%), and drug induced hepatitis (15%).Conclusion: Jaundice is very common disease with male predominance, varied etiology most common being viral hepatitis, Alcoholic liver diseases. Most common presentation is anorexia followed by myalgia, fatigue.

Keywords: Jaundice, viral hepatitis, SGOT, SGPT.