A Hospital Based Prospective Study to Evaluate the Effects of Sevoflurane as an Adjuvant to Propofol Based Total Intravenous Anaesthesia During Ocular Surgery

Abstract

Background:Propofol is one of the most commonly used intravenous anesthetic drugs both for induction and maintenance of general anesthesia. The present study was conducted to evaluate the effect of sevoflurane as an adjuvant to propofol-based total intravenous anaesthesia during ocular surgery.Materials and Methods: The present study was conducted to evaluate the effect of sevoflurane as an adjuvant to propofol-based total intravenous anaesthesia during ocular surgery. The study was conducted over a period of 1 year among 90 patients who were scheduled to undergo ocular surgery by ophthalmologist under GA. Patients were randomized divided into the propofol-based TIVA or propofol /sevoflurane anesthesia groups. All patients were monitored. Data was collected and analysis was done. Results: In the present study 90 patients undergoing elective ocular surgery under GA were included and divided into 2 groups 45 in the TIVA group and 45 in the propofol/sevoflurane group. Mean age of TIVA group was 56yrs and propofol/sevoflurane group was 54 yrs. Maximum patients were ASI II in both groups. The operation time for TIVA group was 55.3±20.6 mins and for propofol/ sevoflurane group was 66.4±28.7mins. Anesthesia time for TIVA group was 86.4±24.6mins and propofol/sevoflurane group was 95.4±32.3mins. Extubation time for TIVA group was 5.43±3.12mins and propofol/sevoflurane group was 6.56±3.12mins and the LOC Ce for TIVA group was 2.67±0.76mins and propofol/sevoflurane group was 3.02±0.92mins. The maintenance propofol Ce values were 2.59±0.79 and 2.28±0.89 μg/mL in the TIVA and propofol/sevoflurane groups, respectively. The awakening propofol Ce values were 0.95±0.43 and 0.67±0.28 μg/mL in the TIVA and propofol/sevoflurane groups, respectively. Nasopharyngeal excretion volume was 29.3±19.5 and 15.5±11.8 in the TIVA and propofol/sevoflurane groups, respectively. Conclusion: The present study concluded that the combination with 1% sevoflurane anesthesia attenuated propofol-induced excess excretions during ocular surgery. And no prolonged extubation under BIS monitoring, no postoperative endophthalmitis, and no PONV in the 2 groups was found.