Age-associated changes in physiological and biochemical arterial stiffness markers in apparently healthy

Abstract

Introduction: Cardiovascular (CV) disease is the first cause of mortality and morbidity worldwide.1 Prevention of this condition, which is responsible of more than 2,200 deaths per day only in the United States, is a public health priority.Materials and Methods: This was an observational, cross-sectional study conducted between conducted over a period of 6 months. Apparently, healthy 70 males and 60 females of age group 30–>60 years without any cardiovascular or peripheral vascular disease or on any antihypertensive and lipid-lowering therapy were recruited in the study. Results: A total of 130 apparently healthy subjects in the age group of 30 to more than 60 years participated in the study. Out of them, 70 were male and 60 were female subjects. The analysis revealed that males had significantly higher values with respect to height (P < 0.0005), weight (P < 0.05) and PPR (P < 0.01) than females. Females had significantly higher values with respect to BMI (P < 0.0005), AIx (P < 0. 0005), central SBP (P < 0.05), central PP (P < 0.01) and brachial PP (P < 0.05) than males. There was no significant difference in other variables between the groups. Significant difference in other variables in different age groups of male participants.Conclusion: The present analysis demonstrated a direct relationship of inflammation and hemostasis with SI measured by digital photo plethysmography, which was modulated by the extent of arterial stiffening.