Study of lipid profile and lipid peroxidation in chronic kidney disease patients on dialysis

Abstract

Introduction: Chronic kidney Disease is defined as abnormalities of kidney structure or function, present for > 3 months, with implications for health.1 The kidney disease out comes quality initiative defines chronic kidney disease as either kidney damage or a decreased kidney Glomerular filtration Rate (GFR) of less than 60 ml/min/1.7m2 or more months.2 The burden of chronic kidney disease in India cannot be assessed accurately. The approximate prevalence of CKD is 800 per million population (PMP), and the incidence of End-stage renal disease (ESRD) is 150 -200 per million population.Materials and Methods: The study was conducted during the period April 2017 to October 2018 in the department of Biochemistry, Prathima medical college, Karimnagar, Telangana. The individuals for study were selected from nephrology department of Prathima Hospital, Karimnagar. The individuals were with e GFR (90ml/min- 15ml/min). After 12 hrs fasting 5 ml. venous blood sample was collected in plain tubes, the samples were allowed to clot for half an hour following which a samples were centrifuged for 15 minutes at 3000 rpm. Results: The total number of cases is 50, Males 35 and Females 15, The total number of controls are 50, Males 35 and Females 15. P value <0.001 is statistically significant. The serum Creatinine is significantly higher (P<0.001) in Cases when compared to controls. Data is presented as Mean ± 95% confidence interval of blood urea levels for cases and controls. Blood Urea is significantly higher (P<0.001) Cases when compared to controls. Data is presented as Mean ± 95% confidence interval of Serum triglycerides levels for Cases and Controls. The mean serum total cholesterol is not significantly altered in Cases when compared with Controls. (P = 0.0535).Conclusion: Based on the findings in this study, it may be reasonable to propose that therapeutic regimens aimed at strengthening the antioxidant defences as well as normalizing lipids concentrations would be useful in protecting CKD patients against oxidative stress and any related complications.