Role of Serum copper in Dysfunctional Uterine Bleeding (DUB)

Abstract

Introduction: DUB is one of the most frequent condition seen in gynecologic outpatient department with 10% to 15% presenting with DUB. It is characterised by anovulation and bleeding outside the regular menstrual cycle in females. Copper ions stimulate proliferation and immigration of endothelial cells in the body. Aim of the study: To estimate serum Copper in Dysfunctional uterine bleeding patients. Objectives: To estimate and compare serum Copper in endometrial thickness in biopsy and ultrasonographically proven Dysfunctional uterine bleeding patients and in controls. Materials & Methods: Serum Copper was estimated by using 3-5 –Di-Br-PAESA4-(3,5-Dibromo-2-pyridylazo)-N-Ethyl-N-(3-Sulphopropyl) aniline method in spectrophotometer and the levels were compared with that of controls. Results: In present study, serum copper levels showed high mean values in DUB cases, compared to normal controls(206.36 ± 77.08 ,151.16 ± 68.34 respectively) (p<0.005). Conclusion: Copper being associated with various angiogenic factors had higher concentration in DUB cases.