Association of inflammatory markers with the severity of Covid -19

Abstract

Background: COVID-19 has affected the entire human population of world. It is a pandemic causing deaths of millions of people across the globe. The levels of some inflammatory markers like CRP, ferritin, LDH, TLC, D-dimer, Procalcitonin, and IL 6 are closely connected with severity of inflammation in COVID 19 patients, according to statistical analyses, and an altered level indicates a poor prognosis. There is need to evaluate the association of severity of COVID 19 with some of the important inflammatory markers like CRP, ferritin, LDH, TLC, D-dimer, Procalcitonin and IL 6. Objective: To evaluate the association of severity of COVID 19 with some of the important inflammatory markers like CRP, ferritin, LDH, TLC, D-dimer, Procalcitonin and IL6. Methods and Materials: The study was conducted in the Department of Biochemistry, S.N.M.M.C., Dhanbad from January 2021 to July 2021. A total of 150 patients with positive RT PCR were included. Serum samples taken and run on MAGLUMI series and reported for CRP, Ferritin, LDH , Procalcitonin, D-dimer, TLC and IL 6 .The quantitative determination of PCT, D-DIMER, IL-6 in human serum and plasma was carried out with MAGLUMI series fully automated chemiluminescence immunoassay analyser, while C reactive (CRP) in human serum of plasma was evaluated by Latex -enhanced turbidimetric immunoassay. Results: There were 150 patients in total, with 59 females and 91 men. All of the parameters were evaluated on all of the patients. Males were 47.77±14.38 years old on average, while females were 42.23± 17.32 years old on average. Only four of the six indicators, CRP, D-Dimer. Ferritin and IL6, achieved statistical significance in the research, with a p value of 0.01. The remaining three indicators, TLC, LDH and procalcitonin, were all non-significant. The p value for D-Dimer was 0.59. TLC p value was 0.07, procalcitonin p value was 0.32. Conclusion: CRP, D-Dimer, Ferritin and IL6 had significance correlation with severity of COVID 19 whereas rest three indicators like TLC, LDH & Procalcitonin had no significant correlation with severity of COVID 19.