A comparison of dexmedetomidine (0.25mcg/kg) and clonidine(1mcg/kg) to attenuate stress response during laryngoscopy and intubation

Abstract

Background: Direct Laryngoscopy And Intubation Are Very Powerful Stimuli Which Leads To Increased Sympathetic Stimulation Resulting In Tachycardia And Hypertension .This response May Be Fatal In High Risk Patients And Can Be Blunted By Appropriate Premedication .The Aim Of This Study Was To Compare Dexmedetomidine 0.25mcg/Kg And Clonidine 1mcg /Kg As A Premedication To Blunt The Haemodynamic Response During Laryngoscopy And Intubation. Methods:100 Adult Patients Of Asa I & II Between 20 To 60 Years Of Age Of Either Sex, Divided Into 2 Groups ,50 Patient In Each Group.Group 1- Received 1 Mcg/Kg Clonidine And Group-II Received 0.25mcg/Kg Of Dexmedetomidine. Haemodynamic Parameters Were Noted Before Induction ,After Induction After Laryngoscopy And Intubation And After 5 Min. Of Laryngoscopy And Intubation. Result: In Our Study Haemodynamic Parameters Indicating Sympathetic Responses Like Hr, Sbp,Dbp ,Map All Incresed During Laryngoscopy And Intubation. Premedication With Clonidine 1mcg/Kg and Dexmedetomidine 0.25mcg/Kg Reduced The Increased Haemodynamic Response But Attenuation Was More With 0.25 Mcg/Kg Dexmedetomidine Group As Compared To Clonidine 1mcg/Kg Group Which Was Significant (P<0.005). Conclusion: We Conclude That Intravenous Dexmedetomidine 0.25 Mcg/Kg Significantly Reduces The Haemodynamic Response During Laryngoscopy And Intubation As Compared To Intravenous Clonidine 1 Mcg./Kg