Change in Requirement of Propofol During Subsequent Sessions of Intracavitary Brachytherapy Applications

Abstract

Cancer cervix patients need intracavitary brachytherapy as a treatment modality for which sedation is needed. Usually each patient requires 4 cycles. Propofol dose requirement was studied in subsequent cycles to see any increase in dose as the cycle progresses. Materials and Methods: After approval of the hospital ethical committee, 60 American Society of Anaesthesiology (ASA) I and II patients were studied for change in their haemodynamic variables and Propofol doses to maintain the sedation level at Modified Ramsay Sedation Score (MRSS) of 8 which is required for brachytherapy procedure. Results: There was no statistically significant change in a haemodynamic variables over subsequent cycles. The Propofol doses initially decreased but then increased to near previous doses only to maintain MRSS of 8. Conclusion: On the basis of present study we concluded that average Propofol doses did not increase in subsequent cycles to maintain the appropriate sedation level for the procedure.