Effect of a Combination of Naltrexone and Bupropion in High Fat Diet Induced Obesity in Rats

Abstract

Background: Obesity is an ever-increasing global health problem. It is progressively becoming a major health problem in India among children and adolescents which leads to substantial increase in morbidity, and mortality. The use of antiobesity drugs in management of obesity is vital. Neuronal pathways are known to play a role in short-term regulation of appetite and satiety. Bupropion and Naltrexone leads to a synergistic effect on control of eating. Objective:(1) To evaluate the anti-obesity effect of a combination of naltrexone and bupropion. (2) To compare the anti-obesity effect of orlistat and a combination of naltrexone and bupropion in animal model of obesity. Methods: This study was a prospective study of 17 weeks duration. Obesity due to high fat diet was induced in rats over a period of 17 weeks. A combination of naltrexone and bupropion was administered for 5 weeks and various parameters like body weight, blood glucose, food intake & BMI were measured over a period of 5 weeks. Results: In this study upon administration of orlistat there was a gradual loss in weight in rats. The combination of Naltrexone and Bupropion showed significant (P<0.05) effect on reduction in body weight, reduction in food intake and reduction of BMI in obese rats