A correlative study of cardiac enzyme markers and lipid profiles in coronary artery disease

Abstract

Background: Coronary heart disease also called Coronary artery disease or Ischemic heart disease is characterized by, an inadequate supply of oxygen-rich blood to the heart muscle (myocardium) because of narrowing or blocking of a coronary artery by fatty plaques Increased triglycerides (TG), low-density lipoprotein (LDL), total cholesterol, decreased high-density lipoprotein (HDL), smoking, obesity are considered to be major risk factors for the development of AMI. Objectives: The present study aimed to assess the levels of serum lipid profiles and cardiac enzyme markers in patients with coronary artery disease. The study also aimed to compare and correlate the levels of lipid profiles and cardiac markers of coronary artery disease patients with healthy normal persons. Materials and Methods: Patients with Coronary artery disease (n=30) and healthy controls (n=30) were the subjects of this study. The blood samples were collected under aseptic precautions into plain vacutainer tubes , heparine tube and then the serum obtained after centrifuging the blood is proceeded for the estimation of lipid profile and cardiac enzymes. Results: Patients with Coronary artery disease had shown significant rise in CK-MB and AST and the lipid parameters like Low Density Lipoprotein (LDL) and Total cholesterol (TC) had shown significant increase in cases compared to normal healthy individuals. The CK-MB showed a significant positive correlation with AST and also showed positive correlation with increase in TC, HDL, LDL. Conclusions: The level of cardiac enzyme markers and lipid parameters in this study clearly shows that there is significant rise in levels of CK-MB, AST, TC , LDL in patients suffering from coronary artery disease. Also there is significant positive correlation between CK-MB and AST which is statistically significant. The estimation of levels of these parameters would serve as tool for future prophylaxis of CAD patients for either treatment or life style modifications.