A study on microalbuminuria as a nephropathic marker in type 2 diabetes mellitus and its correlation with the glycated hemoglobin

Authors

  • Vijaitha S M Assistant Professor, Department of Biochemistry, Maheshwara Medical College, Chitkul, Sangareddy, Telangana, India

Keywords:

Type 2 diabetes mellitus , HbA1c, Microalbuminuria, incipient diabetic nephropathy.

Abstract

Introduction: Diabetic nephropathy is a leading cause of morbidity and premature mortality in diabetic subjects. Glycemic control is closely associated with renal involvement in diabetes and microalbuminuria can be used to detect the early stage also known as incipient nephropathy. Objectives:
1. To estimate the microalbuminuria and HbA1c in patients with type 2 diabetes mellitus and in normal healthy controls.
2. To correlate HbA1c and microalbuminuria with duration of type 2 diabetes mellitus.
3. To study the correlation between HbA1c and microalbuminuria level in patients with Type 2 diabetes mellitus and normal healthy controls.
Materials and methods: It is cross sectional observational study, 50 patients with type 2 Diabetes Mellitus and 50, age and sex matched normal healthy controls were recruited. 5ml of fasting venous blood was collected and used for the analysis of plasma fasting and post prandial glucose and HbA1c was assayed in EDTA blood, serum was used to assay urea, creatinine, sodium, potassium, and early morning mid stream urine sample for estimation of the microalbuminuria. Data was statistically analyzed. Results: In the present study there was significant association (P<0.001) and positive correlation between microalbuminuria and HbA1c in cases as compared to controls. The occurance of microalbuminuria showed a direct relationship with increase duration of diabetes since diagnosis. We also found positive correlation between microalbuminuria with duration of diabetes. Conclusion: Current study shows elevated HbA1c and microalbuminuria with duration of diabetes. The risk of microalbuminuria increases with poor glycemic control are strongly associated with the presence of nephropathy, a microvascular complication of diabetes. Thus HbA1c and microalbuminuria may be considered as risk marker in diabetic nephropathy. Hence regular screening for microalbuminuria and HbA1c can help in clinical management for prevent of complication.

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Published

2021-10-20

How to Cite

Vijaitha S M. (2021). A study on microalbuminuria as a nephropathic marker in type 2 diabetes mellitus and its correlation with the glycated hemoglobin. International Journal of Health and Clinical Research, 4(18), 10–14. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/2874