Hepatitis B Virus Genotypes and Liver Function Tests in Chronic Hepatitis B Patients
Keywords:HBV, genotype, ALT, AST, LFT.
Introduction: Hepatitis B virus (HBV) infection is a major public health problem worldwide. Almost 296 million people around the world are suffering from chronic hepatitis B with addition of 1.5 million cases per year. Chronic HBV infection causes morbidity and mortality mostly from chronic liver diseaseslike cirrhosis and Hepatocellular carcinoma (HCC). At least ten HBV genotypes have been identified so far and genotype D and A are commonly found in India. Materials and Methods: Two years cross sectional study was done and a total of 78 patients were included in this study. Among all 53 were HBsAg positive. All the processes of diagnosis were carried out at Biochemistry and Microbiology section of Central Laboratory (an ISO 15189:2012 certified and NABH accredited laboratory), Shri Mahant Indiresh Hospital and Central Molecular Research Laboratory (CMRL) [a BSL-III laboratory], Department of Biochemistry, Shri Guru Ram Rai Institute of Medical and Health Sciences (SGRRIMHS), Patel Nagar, Dehradun (U.K). Results: Out of 78 subjects, only 53 were positive for HBsAg and of these, DNA was detected only in 43 cases. The genotype D (53.48%) was the most common finding followed by genotype A (23.33%) and genotype F was found in lowest number (2.33%). No significant associations were established between HBV genotypes and Liver function tests (serum ALT, AST, serum Albumin and total serum Bilirubin). Conclusion: This study concludes that no significant associations were found between HBV genotypes and liver function tests in chronic hepatitis B patients in north India.
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Copyright (c) 2021 Furquan Alam, Ruqaiyah Nadeem, Farah Ahsan, Farah Ahsan, R. K. Singh
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