N-Terminal Pro Brain Natriuretic Peptide(NT – ProBNP) For Risk Stratification in Acute Coronary Syndrome (ACS)

Abstract

Background: In detecting the whole spectrum of acute coronary syndromes (ACS) and for mortality prediction, natriuretic peptides (BNP and NT-proBNP) are useful tools for risk stratification of acute myocardial ischemia patients.  Aim: This study assess the use of natriuretic peptides for early risk stratification of patients with acute coronary syndrome. Results: The p-value was >0.05N i.e. non-significant difference between the two groups for all the baseline characteristics of the studied population by NT-proBNP. The difference between the two groups for patients who had ST segment deviation was non-significant. T wave changes were significant between the two groups. In  Group B (with NT-proBNP equal or  more than 474 pg/ml), incidence of heart failure and duration of  hospital stay  were significantly higher when compared to Group A (with NT-proBNP less  than 474 pg/ml),.  In Group  B, the  number of  coronary vessels affected, degree of  stenosis and proximal left  anterior descending artery (LAD)  disease were higher when compared to  Group A. In  Group B compared to  Group A, there was  an  increased incidence of  cardiogenic shock and mortality.Conclusion: This study proved that NT-proBNP in acute coronary syndrome is an appropriate marker associated with more coronary artery involvements based on number of vessels affected and severity of stenosis. It is a valuable marker for higher heart failure incidence and lower ejection fraction.