A study of various hepatic manifestations in dengue fever and their correlation with severity of dengue fever

Abstract

Background: Dengue is the most crucial of the arboviral infections amongst humans. The incidence of Dengue fever and Dengue hemorrhagic fever has drastically increased in the recent years. The higher involvement of younger ages and increase in the incidence of epidemics are indicators of higher occurrence of infection. The mortality rate from complications is as high as 20%, while if they are properly managed, the mortality rate reduces to less than 1%. The present study was conducted with the aim to determine various hepatic manifestations in dengue fever and their correlation with severity of dengue fever. Materials and methods: The present prospective study was conducted on cases of Dengue fever (DF) and Dengue hemorrhagic fever reporting at RIMS Hospital. Adults positive for IgM alone or both IgM and IgG were followed up for clinical profile. Complete blood profile including hematocrit was repeated daily during the acute phase of the illness and chest X-ray was taken to demonstrate pleural effusion amongst the cases. The clinical manifestations and laboratory findings of each group of illness was compared using chi-square or fisher’s exact test for proportions and analysis of variance (ANOVA) for continuous data. Results: There was a male predominance in the study with 66.7% males having dengue fever. There was statistically no significant difference in the demographic variables. Fever was observed in 60% of the cases with Infection and 100% patients had fever in dengue. Vomiting was observed in 93.3% cases with dengue fever and 100% cases had body pains. Conclusion: The incidence of dengue infection in increasing in developing countries like India and different degree of hepatic complications has been observed.