Role of Vit D supplementation in reducing the prevalence of pre-eclampsia in pregnant women: A comparative study.

Abstract

Aim: To determine the effect of vitamin D supplementation during pregnancy in prevention of pre eclampsia in pregnant women.

Materials and methods: The present prospective comparative interventional study was conducted in the Department of Obstetrics & Gynaecology, Jawaharlal Nehru Medical College and Hospital, Bhagalpur, Bihar, India.  from March 2019 to Dec 2019.Total 60 patients were divided into two groups. Group I (n=30): received only routine iron &folic acid and calcium supplementation (irrespective of vitamin D level). Group II (n=30):vitamin D supplementation (irrespective of vitamin D level)in the form of oral cholecalciferol sachet 60,000IU once in every two weeks, from 28 ± 1 weeks upt 36 ±1weeks of gestation, along with routine iron &folic acid and calcium supplementation. Results: Pre-eclampsia was observed in 16.7% of the patients who didn’t receive vitamin D supplementation whereas the group II who received supplementation showed  pre-eclampsia in   6.7% of the patients (p=0.041).Conclusion: This study concludes that there is significant role of vitamin D supplementation in pregnant women in prevention of pre-eclampsia.

Keywords: pre-eclampsia, vitamin D, singleton