Estimation of Hs C Reactive Protein in Patients with Premalignant and Malignant Lesions

Abstract

Introduction: Hs CRP, a typical systemic inflammation marker, were first discovered in the plasma of patients during the acute phase of pneumococcal pneumonia. HsCRP is produced in hepatocytes in response to inflammatory cytokines such as interleukin (IL)-1, tumor necrosis factor (TNF)-α, and IL-6. Thus, its level in tissue fluids marks the underlying conditions of inflammation and cellular proliferation.Methodology: In this study we were included total 4 groups. For each group we had taken 50 cases. In this study, Group I included healthy control, Group II included Oral leukoplakia, Group III included Oral submucous fibrosis & Group IV were included patients with Oral cancer. This study was conducted in Department of Biochemistry, Career Institute of Medical Sciences & Hospital, Lucknow. Results: High-sensitivity C-reactive protein (hs-CRP), an acute-phase plasma protein that increases during systemic inflammation, is one of the most frequently used inflammatory markers. The result of this study revealed that the hs CRP levels were analyzed for each group and the mean and standard deviation were analysed. All values are significant in this study.Conclusion: This study concludes that Hs CRP levels are deranged significantly in pre-malignant as well as malignant condition. The analysis of these biomarkers shows an increasing trend from healthy control to PMDs and malignant condition.