Study the prognostic significance of various biochemical parameters in organophosphorus poisoning

Abstract

Background: Acute organophosphorus poisoning is an important cause of morbidity and mortality in developing countries like India. Objective: To study clinical features and biochemical parameters in patients admitted with acute organophosphorus poisoning and to determine use of these biochemical marker in prediction of severity of acute OP poisoning. Material and method: 94 cases of OP poisoning admitted to KIMS Hospital, Hubbali between January 1st 2017 to December 31th 2017 were studied. Results: OP poisoning is more common in adults of age group between 20 – 30 years, Incidence is was more in male patients, Mortality rate is 12.8%. Mean values of Serum amylase, serum LDH, serum CPK and serum creatinine were negatively correlated with pseudcholinesterase levels and it was statistically significant. correlation between the severity of OP poisoning (based on Peradenyia score) and biochemical parameters like pseudocholinesterase, serum amylase, serum CPK, serum LDH, RBS was statistically significant. But Serum Creatinine levels did not show statistically significant correlation. Conclusions: The correlation between the severity of OP poisoning and biochemical parameterswas statistically significant and they are usefull in predicting development of respiratory failure.