Association of mean platelet volume in patients with acute coronary syndrome: A Case control study

Abstract

Background: Ischemic Heart Diseases are the leading cause of morbidity and mortality worldwide. In comparison with the people of European ancestry, CVD affects Indians at least a decade earlier and in their most productive midlife. Nearly two-thirds of the burden of NCD mortality in India is currently contributed by CVD-related conditions. Platelet hyper-reactivity and local platelet activation have been suggested to play a crucial role in acute coronary events (including ACS). Objectives: So this study was undertaken to determine the association of MPV in patients with ACS in relation to various types. Methods: This study is under taken among 70 ACS patients admitted and compared with 70 controls, after excluding the patients affected by diseases which are known to alter platelets structure and function. Results: The mean age of the patients among cases was found to be 64.8±10.8 years and 61.9±10.6 years among controls (p value– 0.11). On comparing, MPV was found to be 8.9±0.9 fL in control and was 12±1.4, 11.5±1.2, 10.3±0.8 fL among STEMI, NSTEMI and Unstable Angina patients respectively (p value<0.001). Conclusion: MPV is significantly higher in (ACS) cases compared to control group, among cases it was significantly high in STEMI, followed by NSTEMI and Unstable Angina. Platelet Indices help in anticipating severity (risk stratification) of CAD and also may help in diagnosis ACS patients, where myocardial injury markers are not available.