Study of evaluation of renal function in patients with subclinical and overt hypothyroidism and to correlate these values with the thyroid profile of the patients.

Abstract

Aim: to analyse the changes in biochemical markers of renal function in patients with subclinical and overt hypothyroidism and to correlate these values with the thyroid profile of the patients

Methods: The present analytical cross-sectional was conducted in the Department of Biochemistry, Patna. Medical College and Hospital, Patna, Bihar, India from April  2019 to November  2019. The study includes 100 subclinical hypothyroid patients and 100 overt hypothyroidism (OHT) cases, 200 euthyroid patients (ET). Thyroid function test, serum creatinine and eGFR were measured in all the three groups.

Results: There is no significance change in age group among the three groups. We found significant difference in the mean of TSH, free T₃. Free T₄, serum creatinine and eGFR among the three groups (p < 0.05). Patients suffering from OHT have the highest percentage of increase in serum creatinine in comparison to other  two  groups.  the maximum percentage of patients having decreased GFR(<90  mg/ml/m²)  belongs to the group of patients with OHT and the maximum percentage of patients having normal eGFR belongs to the group of patients with euthyroid condition.The positive significant correlations of Creatinine with TSH (p<0.05) and the negative significant correlations of eGFR with TSH (p<0.05). There is a poor correlation of creatinine and eGFR with thyroid hormones (p>0.05). There is negative significant correlations of creatinine with Free T₄ (p< 0.05) and the positive correlations of eGFR with Free T4 (p< 0.05). There is poor correlation of creatinine and eGFR with Free T3 (p>0.05).

Conclusions: the renal function and thyroid function are interrelated with each other in SCH cases. SCH patients should be monitored for renal parameters regularly to prevent long term complications. Early diagnosis and early treatment of the disease and can increase the quality of life.

Keywords: Overt hypothyroidism, Renal function tests, Subclinical hypothyroidism, Thyroid function tests