Comparative evaluation of efficacy and safety of Atracurium besylate and different doses of Cisatracurium besylate using peripheral nerve stimulator

Abstract

Background and Aims: Neuromuscular blockers have become essential part of anaesthesiologist armamentarium. They aid endotracheal intubation, mechanical ventilation, reduce anaesthetic requirement, prevent patient movement and facilitate surgery. The ideal neuromuscular relaxant is an agent which has a quick onset time and short duration of action. We compare the efficacy of Atracurium besylate and different doses of Cisatracurium besylate in patients undergoing elective abdominal surgeries under general anesthesia, Considering onset time, intubating conditions and duration of action. Material and methods: Randomized trial was conducted in ninety patients of ASA grade I and II ,posted for elective abdominal surgeries were randomly allocated into three groups, of 30 patients each, depending on muscle relaxant and its doses used for intubation. Results: In present study, we found that cisatracurium with the dose of 0.2 mg/kg B.W. is better neuromuscular blocking agent for intubation than cisatracurium 0.1mg/kg B.W. and atracurium 0.5 mg/kg B.W. Conclusion: Faster onset, longer duration of action with larger doses of cisatracurium and with good to excellent intubating conditions makes cisatracurium a more promising alternative muscle relaxant agent for tracheal intubation in clinical practice.