Effects of Intravenously Administered Dexmedetomidine and Clonidine on Haemodynamic Response and Post Operative Analgesia in Laparoscopic Surgery: An Observational Study

Authors

  • Afsan Parveen Senior resident, LN Medical College and J.K Hospital, Bhopal, Madhya Pradesh, India
  • Pooja Makhija Post Graduate Third Year Resident, LN Medical College and J.K Hospital, Bhopal, Madhya Pradesh, India
  • Nishtha Sharma Post Graduate Third Year Resident, LN Medical College and J.K Hospital, Bhopal, Madhya Pradesh, India
  • Renu Dhamnani Post Graduate Third Year Resident, LN Medical College and J.K Hospital, Bhopal, Madhya Pradesh, India
  • Nupur Chakravorty HOD Department of Anaesthesiology, LN Medical College and J.K Hospital, Bhopal, Madhya Pradesh, India

Keywords:

Laproscopic Surgery, Dexmedetomidine, Clonidine, Haemodynamic Response.

Abstract

Introduction: Laparoscopic surgery is become the normal now due to its advantages. To counter its disadvantages on haemodynamics, α-2 receptor agonists clonidine and dexmedetomidine are increasingly being used during laparoscopic procedures. Aim: To compare the haemodynamic response, perioperative analgesia, and sedative effects of intravenous dexmedetomidine versus intravenous clonidine given as premedication among patients receiving general anaesthesia for elective laparoscopic surgeries. Materials and methods: The study was an observational, prospective, comparative study in which Group D was given Injection dexmedetomidine 1 μ/kg in 100 ml of normal saline intravenously and Group C was given Injection clonidine 2μ/kg in 100ml of normal saline intravenously before induction of general anaesthesia. Results: Data was calculated as mean, median, and standard deviation. Any statistical difference between the two proportions was estimated using the Chi-square test and any statistical difference between had better hemodynamic control and post-operative analgesia. Both dexmedetomidine and clonidine attenuated the cardiovascular and pressor response to intubation. Dexmedetomidine caused deeper sedation and better analgesia in comparison to clonidine. Conclusion: Alpha 2 agonist dexmedetomidine and clonidine provide haemodynamic stability among patients undergoing laparoscopic surgery. Dexmedetomidine provided much better cardiovascular stability and superior analgesia.

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Published

2022-01-18

How to Cite

Afsan Parveen, Pooja Makhija, Nishtha Sharma, Renu Dhamnani, & Nupur Chakravorty. (2022). Effects of Intravenously Administered Dexmedetomidine and Clonidine on Haemodynamic Response and Post Operative Analgesia in Laparoscopic Surgery: An Observational Study. International Journal of Health and Clinical Research, 5(1), 102–106. Retrieved from https://ijhcr.com/index.php/ijhcr/article/view/3950

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